Honestly this is gonna depend on what type of play style you want to have. The +Def/-Res version can make for a great bait&tank unit (I use this exact same IV set on mine and love it). Ike's Heavy Blade skill can be a little gimmicky at times but with +Atk boon it will active on a fairly reliable rate due to Ike's already solid Atk stat. The -Def bane wont hurt him much as he still will be left with a solid Def of 29. Just make sure to keep him away from most magic users and he should be fine. Overall its really gonna come down to whether you want a player phase unit or an enemy phase unit. You really cant go wrong either way.
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