Which H!Sakura?

+res -def. You are going to be primarily using her as a magic counter. Not a speed demon. So getting the +res can also help her against raven tomes to live a little longer. Although not being doubled is nice, if you have guard, they shouldn’t be triggering specials

Definitely +Spd/-HP, her HP is so low the 3 points don’t really matter, she’s still gonna die anyways. Her Res is so high there isn’t really a point in increasing it further, also keep in mind she even has warding stance which grants her extra Res when attacked. The extra 3 Speed will help her in killing magic users and avoid double attacks from speedy mages.

+RES -DEF seems more ideal as this can allow Sakura soak up magical attacks and can run Quick Riposte along with her Warding Stance and Distant Def seal.

If you want Sakura to play more offensively, she can opt to run +SPD -HP. But personally, I like the idea of a defensive H.Sakura better than offensive.

Both are really great IV sets for her, congrats!

If you want to use her more as enemy phase baiter, +RES -DEF is very good, but if you want to have more freedom in the player phase, +SPD -HP is better.