I am using Guard on my +Res/-HP Amelia and I'm loving it. With Earth Boost she can even tank a +spd L&D Bride Cordelia merged +10 with quickened pulse + Moonbow. If Cordelia gets any buffs, she can take Amelia down, but if you run Armor Emblem with a Hone and Goad, she'll handle even a fully buffed Cordelia. Pretty handy! Also, this setup should be able to do well against the upcoming Lyn invasion.
You can also run a healing special to recover a bunch of that health that you just lost from eating a quad bow...which isn't something a lot of units can say!
I'm still experimenting with her, but I'm really liking this setup. Went deathless in tier 19 (4866 score - YES tier 20!) and I'm still working on giving her Reposition as a support skill. As pictured, Moonbow actually works quite nicely, or a different damage special may work better with your particular bane.
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