For Nowi +spd it depends on the mode. In arena I think you definitely go null follow-up. Allows you to chip QR tanks to help the bonus unit, protects against bold fighter. Guard accomplishes similar objectives for less orbs, but she'll take more hits. In PvE, null follow-up is mostly a waste. Few units will try to force doubles against you. Just use QR.
I have Nowi+5 on +spd -res, just to give some perspective.
Merges do affect scoring. You can test it out here
http://www.arcticsilverfox.com/score_calc/
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