You're probably better off staying with your +Atk -Res, in my opinion. Lucina's Res is already so low that it's her dump stat. You don't really want her to tank mages in the first place. A bane in Def would mean 22 Def, which is incredibly low for a melee unit. In other words, Lucina would be suffering from a low 22 Def and 19 Res. Overall, it's just better to leave her 25 neutral Def as it is.
It's true that Speed is arguably the better stat to keep up with the likes of Ayra or Karla, but whether you want to sacrifice her Def or not is entirely up to you. You can, however, patch up all her stats with the Bond Falchion refine but it would also require a teammate to always be by her side.
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