I don't know if a battle simulator is really a reliable source for determining the best IVs/skill sets since you'd have to manually enter in every unit's most preferred IVs/set to get the full effect of the battle simulator, and that's a bit tedious.
As for which one, I'd think neutral is better, but a -Spd Ishtar is workable, considering she gets +10 speed on initiation. Guess it mostly depends on preference.
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