You will want to wait for one that is not -Spd before you upgrade her to 5* or anything. She can't afford to drop that speed if you want her to be able to tank any physical damage. At 25 speed, she gets double and KO'd by a neutral speed Shiro. You can go -Res if you want to run Fury, or you can go -HP and let the refine make up for it. With -Spd, you will need QR on her so probably don't run Fury or you are for sure out of QR2 range after a single combat.
You will definitely want to upgrade a Tiki or Nowi to give her lightning breath. If you don't have any Steady/Warding Breath fodder, maybe try one of the Brazen skills.
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