Does Ephraim's refine work with desperation?

Do you mean his regular Siegmund refine or flaming Siegmund? Because one doesn't work and the other one does work with desperation.

Sorry, it won't. You need to be below 75% for desperation to kick in but then his refine's effect won't activate since you'll be under the 90% threshold.

OG Ephraim? No, just no.

His weapon needs him to be above 90% hp, lower than that and it won't work, while Desperation needs the unit to be lower than 75% of HP to be used.

Maybe he means Brave Ephraim? His weapon effect, automatic follow up if he’s buffed. Allowing him to utilize it along with desperation.

If so, I don’t see why it wouldn’t work. His B skill is so powerful that most people won’t replace it.