The prf doesn't change too much for her choices of B-skill. The only skill that I think has gained in value is renewal, because if she somehow takes damage (ex: quads some slow unit with flier buffs) she might potentially want to get her HP back up for panic ploying.
Hit and run is a great choice for Player-Phase Fliers!
Fliers can abuse their mobility to retreat over mountains/rivers/trees, etc. Hit and run allows Cherche to nuke a unit, then quickly retreat into a better position where she can be repositioned out of harm's way.
I use Chill Def 3, but since you have Veronica you probably don’t need the debuff. Hit and Run is a solid choice, especially if your other units are using Reposition so you can pull her out of harms way after attacking.