Definitely +Def/-Spd for B!Ike. V!Ike is a tad trickier, the two IV sets are both good. I’d say it depends if you want him to be more reliable vs merged Mages or Melees.
Shiro is in a tad of a weird spot. I’d probably use the +Speed/-Res one. While a speed boon won’t stop him getting doubled by the faster mages out, it helps vs other slower units. A Res Boon with a Speed Bane is unsynergistic, he will be tankier vs Mages and Dragons but will 100% get doubled by them. -Atk is obviously the worst ;).
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