I honestly don't think Wrath is worth it over Desperation, having to hit for twice is usually enough to down a hero without a problem, but it's the same situation like Wrath's boosted damage on special doesn't kill the hero, if Desperation doesn't kill your target within the first two strikes you're probably going down.
So really Desperation is just overall better until we get a seal for Wrath or Desperation. Really the only hero who has access to both combos of Wrath and Desperation is Lyn when Brash became a seal.
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