I have this exact IV as well and have been using her rather successfully for quite a long time. Neph's dmg potential comes from special procs (with wrath) anyway and more defense makes her stay in fight considerably longer.
You should build her up. You don't really have to give her any insanely expensive skills. Even her special refine works well, if you go with bonfire as her special, because once wrath is active, bonfire becomes a 1 turn special, which means that baiting a hit during enemy phase is your best bet, because you can blast off bonfire right (30+ raw damage) upon retaliation.
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Fate Grand Order
Dragonball Legends
IV Calc
Heroes